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Synthesis and Cytostatic Evaluation of 4-N-Alkanoyl and 4-N-Alkyl Gemcitabine Analogues

Couplings of gemcitabine with the functionalized carboxylic acids (C9-C13) or reactions of 4-N-tosylgemcitabine with the corresponding alkyl amines afforded 4-N-alkanoyl and 4-N-alkyl gemcitabine derivatives. The analogues with a terminal hydroxyl group on the alkyl chain were efficiently fluorinate...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Pulido, Jesse, Sobczak, Adam J., Balzarini, Jan, Wnuk, Stanislaw F.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3918440/
https://ncbi.nlm.nih.gov/pubmed/24341356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401586a
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