Suppressing IL-36-driven inflammation using peptide pseudosubstrates for neutrophil proteases

Sterile inflammation is initiated by molecules released from necrotic cells, called damage-associated molecular patterns (DAMPs). Members of the extended IL-1 cytokine family are important DAMPs, are typically only released through necrosis, and require limited proteolytic processing for activation....

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Sullivan, Graeme P., Henry, Conor M., Clancy, Danielle M., Mametnabiev, Tazhir, Belotcerkovskaya, Ekaterina, Davidovich, Pavel, Sura-Trueba, Sylvia, Garabadzhiu, Alexander V., Martin, Seamus J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841435/
https://ncbi.nlm.nih.gov/pubmed/29515113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0385-4
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