Identification of small‐molecule elastase inhibitors as antagonists of IL‐36 cytokine activation

IL‐1 family cytokines act as apical initiators of inflammation in many settings and can promote the production of a battery of inflammatory cytokines, chemokines and other inflammatory mediators in diverse cell types. IL‐36α, IL‐36β and IL‐36γ, which belong to the extended IL‐1 family, have been imp...

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Detalhes bibliográficos
Publicado no:FEBS Open Bio
Main Authors: Sullivan, Graeme P., Davidovich, Pavel B., Sura‐Trueba, Sylvia, Belotcerkovskaya, Ekaterina, Henry, Conor M., Clancy, Danielle M., Zinoveva, Anna, Mametnabiev, Tazhir, Garabadzhiu, Alexander V., Martin, Seamus J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5929933/
https://ncbi.nlm.nih.gov/pubmed/29744290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12406
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