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Cortactin regulates endo-lysosomal sorting of AMPARs via direct interaction with GluA2 subunit

AMPA receptor (AMPAR) trafficking is a key determinant of synaptic strength and synaptic plasticity. Under basal conditions, constitutive trafficking maintains surface AMPARs by internalization into the endosomal system, where the majority are sorted and targeted for recycling back to the plasma mem...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Parkinson, Gabrielle T., Chamberlain, Sophie E. L., Jaafari, Nadia, Turvey, Matthew, Mellor, Jack R., Hanley, Jonathan G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841360/
https://ncbi.nlm.nih.gov/pubmed/29515177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22542-z
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