Unbiased screen identifies aripiprazole as a modulator of abundance of the polyglutamine disease protein, ataxin-3

No disease-modifying treatment exists for the fatal neurodegenerative polyglutamine disease known both as Machado-Joseph disease and spinocerebellar ataxia type 3. As a potential route to therapy, we identified small molecules that reduce levels of the mutant disease protein, ATXN3. Screens of a sma...

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Dades bibliogràfiques
Publicat a:Brain
Autors principals: Costa, Maria do Carmo, Ashraf, Naila S., Fischer, Svetlana, Yang, Yemen, Schapka, Emily, Joshi, Gnanada, McQuade, Thomas J., Dharia, Rahil M., Dulchavsky, Mark, Ouyang, Michelle, Cook, David, Sun, Duxin, Larsen, Martha J., Gestwicki, Jason E., Todi, Sokol V., Ivanova, Magdalena I., Paulson, Henry L.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5840879/
https://ncbi.nlm.nih.gov/pubmed/27645800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/aww228
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