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Energetics and conformational pathways of functional rotation in the multidrug transporter AcrB
The multidrug transporter AcrB transports a broad range of drugs out of the cell by means of the proton-motive force. The asymmetric crystal structure of trimeric AcrB suggests a functionally rotating mechanism for drug transport. Despite various supportive forms of evidence from biochemical and sim...
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| 發表在: | eLife |
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| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
eLife Sciences Publications, Ltd
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5839741/ https://ncbi.nlm.nih.gov/pubmed/29506651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31715 |
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