Energetics and conformational pathways of functional rotation in the multidrug transporter AcrB

The multidrug transporter AcrB transports a broad range of drugs out of the cell by means of the proton-motive force. The asymmetric crystal structure of trimeric AcrB suggests a functionally rotating mechanism for drug transport. Despite various supportive forms of evidence from biochemical and sim...

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Bibliographic Details
Published in:eLife
Main Authors: Matsunaga, Yasuhiro, Yamane, Tsutomu, Terada, Tohru, Moritsugu, Kei, Fujisaki, Hiroshi, Murakami, Satoshi, Ikeguchi, Mitsunori, Kidera, Akinori
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2018
Subjects:
Computational and Systems Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839741/
https://ncbi.nlm.nih.gov/pubmed/29506651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31715
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