Testosterone Rapidly Augments Retrograde Endocannabinoid Signaling in Proopiomelanocortin Neurons to Suppress Glutamatergic Input from Steroidogenic Factor 1 Neurons via Upregulation of Diacylglycerol Lipase-α

Testosterone exerts profound effects on reproduction and energy homeostasis. Like other orexigenic hormones, it increases endocannabinoid tone within the hypothalamic feeding circuitry. Therefore, we tested the hypothesis that testosterone upregulates the expression of diacylglycerol lipase (DAGL)α...

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Pubblicato in:Neuroendocrinology
Autori principali: Conde, Kristie, Fabelo, Carolina, Krause, William C., Propst, Robert, Goethel, Jordan, Fischer, Daniel, Hur, Jin, Meza, Cecilia, Ingraham, Holly A., Wagner, Edward J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839320/
https://ncbi.nlm.nih.gov/pubmed/27871072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000453370
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