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The diacylglycerol lipases: structure, regulation and roles in and beyond endocannabinoid signalling

The diacylglycerol lipases (DAGLs) hydrolyse diacylglycerol to generate 2-arachidonoylglycerol (2-AG), the most abundant ligand for the CB(1) and CB(2) cannabinoid receptors in the body. DAGL-dependent endocannabinoid signalling regulates axonal growth and guidance during development, and is require...

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Détails bibliographiques
Auteurs principaux: Reisenberg, Melina, Singh, Praveen K., Williams, Gareth, Doherty, Patrick
Format: Artigo
Langue:Inglês
Publié: The Royal Society 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481529/
https://ncbi.nlm.nih.gov/pubmed/23108545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2011.0387
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