Acute inhibition of diacylglycerol lipase blocks endocannabinoid-mediated retrograde signalling: evidence for on-demand biosynthesis of 2-arachidonoylglycerol

The endocannabinoid (eCB) 2-arachidonoylglycerol (2-AG) produced by diacylglycerol lipase α (DGLα) is one of the best-characterized retrograde messengers at central synapses. It has been thought that 2-AG is produced ‘on demand’ upon activation of postsynaptic neurons. However, recent studies propos...

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Detalhes bibliográficos
Main Authors: Hashimotodani, Yuki, Ohno-Shosaku, Takako, Tanimura, Asami, Kita, Yoshihiro, Sano, Yoshikazu, Shimizu, Takao, Di Marzo, Vincenzo, Kano, Masanobu
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2013
Assuntos:
Neuroscience: Cellular/Molecular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3800453/
https://ncbi.nlm.nih.gov/pubmed/23858009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2013.254474
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