Fever Is Mediated by Conversion of Endocannabinoid 2-Arachidonoylglycerol to Prostaglandin E(2)

Fever is a common response to inflammation and infection. The mechanism involves prostaglandin E(2) (PGE(2))-EP3 receptor signaling in the hypothalamus, which raises the set point of hypothalamic thermostat for body temperature, but the lipid metabolic pathway for pyretic PGE(2) production remains u...

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Publicat a:PLoS One
Autors principals: Kita, Yoshihiro, Yoshida, Kenij, Tokuoka, Suzumi M., Hamano, Fumie, Yamazaki, Maya, Sakimura, Kenji, Kano, Masanobu, Shimizu, Takao
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4511515/
https://ncbi.nlm.nih.gov/pubmed/26196692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133663
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