Testosterone Rapidly Augments Retrograde Endocannabinoid Signaling in Proopiomelanocortin Neurons to Suppress Glutamatergic Input from Steroidogenic Factor 1 Neurons via Upregulation of Diacylglycerol Lipase-α

Testosterone exerts profound effects on reproduction and energy homeostasis. Like other orexigenic hormones, it increases endocannabinoid tone within the hypothalamic feeding circuitry. Therefore, we tested the hypothesis that testosterone upregulates the expression of diacylglycerol lipase (DAGL)α...

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Publié dans:Neuroendocrinology
Auteurs principaux: Conde, Kristie, Fabelo, Carolina, Krause, William C., Propst, Robert, Goethel, Jordan, Fischer, Daniel, Hur, Jin, Meza, Cecilia, Ingraham, Holly A., Wagner, Edward J.
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839320/
https://ncbi.nlm.nih.gov/pubmed/27871072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000453370
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