Tau Depletion in APP Transgenic Mice Attenuates Task-Related Hyperactivation of the Hippocampus and Differentially Influences Locomotor Activity and Spatial Memory

Hippocampal hyperactivity, ascribed to amyloid β (Aβ)-induced imbalances in neural excitation and inhibition, is found in patients with mild cognitive impairment, a prodromal stage of Alzheimer's disease (AD). To better understand the relationship between hippocampal hyperactivity and the molec...

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Veröffentlicht in:Front Neurosci
Hauptverfasser: Yoshikawa, Misato, Soeda, Yoshiyuki, Michikawa, Makoto, Almeida, Osborne F. X., Takashima, Akihiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5838015/
https://ncbi.nlm.nih.gov/pubmed/29545742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2018.00124
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