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Theory and Application of the Relationship between Steady-State Isotope Effects on Enzyme Intermediate Concentrations and Net Rate Constants()

Steady-state kinetic isotope effects on enzyme catalyzed reactions are often interpreted in terms of the microscopic rate constants associated with the elementary reactions of interest. Unfortunately, this approach can lead to confusion, especially when more than one elementary reaction is isotopica...

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Vydáno v:Methods Enzymol
Hlavní autoři: Ruszczycky, Mark W., Liu, Hung-wen
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837895/
https://ncbi.nlm.nih.gov/pubmed/28911781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.mie.2017.07.022
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