The cryo-electron microscopy structure of huntingtin

Huntingtin (Htt) is a large (348 kDa) protein, essential for embryonic development and involved in diverse cellular activities such as vesicular transport, endocytosis, autophagy and transcription regulation1,2. While an integrative understanding of Htt's biological functions is lacking, the la...

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Publicado en:Nature
Autores principales: Guo, Qiang, Huang, Bin, Cheng, Jingdong, Seefelder, Manuel, Engler, Tatjana, Pfeifer, Günter, Oeckl, Patrick, Otto, Markus, Moser, Franziska, Maurer, Melanie, Pautsch, Alexander, Baumeister, Wolfgang, Fernández-Busnadiego, Rubén, Kochanek, Stefan
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837020/
https://ncbi.nlm.nih.gov/pubmed/29466333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature25502
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