The cryo-electron microscopy structure of huntingtin

Huntingtin (Htt) is a large (348 kDa) protein, essential for embryonic development and involved in diverse cellular activities such as vesicular transport, endocytosis, autophagy and transcription regulation1,2. While an integrative understanding of Htt's biological functions is lacking, the la...

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Dades bibliogràfiques
Publicat a:Nature
Autors principals: Guo, Qiang, Huang, Bin, Cheng, Jingdong, Seefelder, Manuel, Engler, Tatjana, Pfeifer, Günter, Oeckl, Patrick, Otto, Markus, Moser, Franziska, Maurer, Melanie, Pautsch, Alexander, Baumeister, Wolfgang, Fernández-Busnadiego, Rubén, Kochanek, Stefan
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837020/
https://ncbi.nlm.nih.gov/pubmed/29466333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature25502
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