The cryo-electron microscopy structure of huntingtin

Huntingtin (Htt) is a large (348 kDa) protein, essential for embryonic development and involved in diverse cellular activities such as vesicular transport, endocytosis, autophagy and transcription regulation1,2. While an integrative understanding of Htt's biological functions is lacking, the la...

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Detalles Bibliográficos
Publicado en:Nature
Main Authors: Guo, Qiang, Huang, Bin, Cheng, Jingdong, Seefelder, Manuel, Engler, Tatjana, Pfeifer, Günter, Oeckl, Patrick, Otto, Markus, Moser, Franziska, Maurer, Melanie, Pautsch, Alexander, Baumeister, Wolfgang, Fernández-Busnadiego, Rubén, Kochanek, Stefan
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837020/
https://ncbi.nlm.nih.gov/pubmed/29466333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature25502
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