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Structural Insight into Transmissive Mutant Huntingtin Species by Correlative Light and Electron Microscopy and Cryo-electron Tomography
Aggregates of mutant huntingtin (mHTT) containing an expanded polyglutamine (polyQ) tract are hallmarks of Huntington’s Disease (HD). Studies have shown that mHTT can spread between cells, leading to the propagation of misfolded protein pathology. However, the structure of transmissive mHTT species,...
שמור ב:
| הוצא לאור ב: | Biochem Biophys Res Commun |
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| Main Authors: | , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2021
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8176346/ https://ncbi.nlm.nih.gov/pubmed/33984771 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2021.04.124 |
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