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The mTOR kinase determines effector versus memory cell fate of CD8(+) T cells by regulating T-bet and Eomesodermin expression

The mechanisms underpinning integration of instructions that program naïve CD8(+) T cells for effector and/or memory differentiation are not well understood. Herein, we demonstrate that IL-12, the critical determinant that instructs antigen-stimulated naïve CD8(+) (OT-I) T cells for T-bet dependent...

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Bibliografiske detaljer
Udgivet i:Immunity
Main Authors: Rao, Rajesh R, Li, Qingsheng, Odunsi, Kunle, Shrikant, Protul A
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5836496/
https://ncbi.nlm.nih.gov/pubmed/20060330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.10.010
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