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The mTOR kinase determines effector versus memory cell fate of CD8(+) T cells by regulating T-bet and Eomesodermin expression
The mechanisms underpinning integration of instructions that program naïve CD8(+) T cells for effector and/or memory differentiation are not well understood. Herein, we demonstrate that IL-12, the critical determinant that instructs antigen-stimulated naïve CD8(+) (OT-I) T cells for T-bet dependent...
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| Publicat a: | Immunity |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5836496/ https://ncbi.nlm.nih.gov/pubmed/20060330 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.10.010 |
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