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A Central Role for mTOR Kinase in Homeostatic Proliferation Induced CD8(+) T cell Memory and Tumor Immunity
The cell-intrinsic mechanisms guiding naïve CD8(+) T cells for clonal expansion and memory generation via Homeostatic Proliferation (HP) are unclear. Herein, we have shown that HP of naïve CD8(+) T cells requires IL-7, but not IL-15 induced mTOR kinase activation. HP-induced mTOR enhances transcript...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3083826/ https://ncbi.nlm.nih.gov/pubmed/21511183 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.04.006 |
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