A Central Role for mTOR Kinase in Homeostatic Proliferation Induced CD8(+) T cell Memory and Tumor Immunity

The cell-intrinsic mechanisms guiding naïve CD8(+) T cells for clonal expansion and memory generation via Homeostatic Proliferation (HP) are unclear. Herein, we have shown that HP of naïve CD8(+) T cells requires IL-7, but not IL-15 induced mTOR kinase activation. HP-induced mTOR enhances transcript...

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Main Authors: Li, Qingsheng, Rao, Rajesh R., Araki, Koichi, Pollizzi, Kristen, Odunsi, Kunle, Powell, Jonathan D., Shrikant, Protul A.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083826/
https://ncbi.nlm.nih.gov/pubmed/21511183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.04.006
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