Desmin- and vimentin-mediated hepatic stellate cell-targeting radiotracer (99m)Tc-GlcNAc-PEI for liver fibrosis imaging with SPECT

Extracellular matrix (ECM) accumulation in liver fibrosis is caused by the activation of hepatic stellate cells (HSCs). The goal of this study was to develop a (99m)Tc-labeled N-acetylglucosamine (GlcNAc) that specifically interacts with desmin and vimentin expressed on activated HSCs to monitor the...

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Enregistré dans:
Détails bibliographiques
Publié dans:Theranostics
Auteurs principaux: Zhang, Deliang, Zhuang, Rongqiang, Guo, Zhide, Gao, Mengna, Huang, Lumei, You, Linyi, Zhang, Pu, Li, Jindian, Su, Xinhui, Wu, Hua, Chen, Xiaoyuan, Zhang, Xianzhong
Format: Artigo
Langue:Inglês
Publié: Ivyspring International Publisher 2018
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835940/
https://ncbi.nlm.nih.gov/pubmed/29507624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.22806
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