Desmin- and vimentin-mediated hepatic stellate cell-targeting radiotracer (99m)Tc-GlcNAc-PEI for liver fibrosis imaging with SPECT

Extracellular matrix (ECM) accumulation in liver fibrosis is caused by the activation of hepatic stellate cells (HSCs). The goal of this study was to develop a (99m)Tc-labeled N-acetylglucosamine (GlcNAc) that specifically interacts with desmin and vimentin expressed on activated HSCs to monitor the...

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Publicado en:Theranostics
Autores principales: Zhang, Deliang, Zhuang, Rongqiang, Guo, Zhide, Gao, Mengna, Huang, Lumei, You, Linyi, Zhang, Pu, Li, Jindian, Su, Xinhui, Wu, Hua, Chen, Xiaoyuan, Zhang, Xianzhong
Formato: Artigo
Lenguaje:Inglês
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835940/
https://ncbi.nlm.nih.gov/pubmed/29507624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.22806
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