Desmin- and vimentin-mediated hepatic stellate cell-targeting radiotracer (99m)Tc-GlcNAc-PEI for liver fibrosis imaging with SPECT

Extracellular matrix (ECM) accumulation in liver fibrosis is caused by the activation of hepatic stellate cells (HSCs). The goal of this study was to develop a (99m)Tc-labeled N-acetylglucosamine (GlcNAc) that specifically interacts with desmin and vimentin expressed on activated HSCs to monitor the...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Theranostics
Main Authors: Zhang, Deliang, Zhuang, Rongqiang, Guo, Zhide, Gao, Mengna, Huang, Lumei, You, Linyi, Zhang, Pu, Li, Jindian, Su, Xinhui, Wu, Hua, Chen, Xiaoyuan, Zhang, Xianzhong
Format: Artigo
Jezik:Inglês
Izdano: Ivyspring International Publisher 2018
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835940/
https://ncbi.nlm.nih.gov/pubmed/29507624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.22806
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