Structure of the human activated spliceosome in three conformational states

During each cycle of pre-mRNA splicing, the pre-catalytic spliceosome (B complex) is converted into the activated spliceosome (B(act) complex), which has a well-formed active site but cannot proceed to the branching reaction. Here, we present the cryo-EM structure of the human B(act) complex in thre...

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Vydáno v:Cell Res
Hlavní autoři: Zhang, Xiaofeng, Yan, Chuangye, Zhan, Xiechao, Li, Lijia, Lei, Jianlin, Shi, Yigong
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2018
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835773/
https://ncbi.nlm.nih.gov/pubmed/29360106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2018.14
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