PD-1 (PDCD1) Promoter Methylation Is a Prognostic Factor in Patients With Diffuse Lower-Grade Gliomas Harboring Isocitrate Dehydrogenase (IDH) Mutations

Immune checkpoints are important targets for immunotherapies. However, knowledge on the epigenetic modification of immune checkpoint genes is sparse. In the present study, we investigated promoter methylation of CTLA4, PD-L1, PD-L2, and PD-1 in diffuse lower-grade gliomas (LGG) harboring isocitrate...

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Udgivet i:EBioMedicine
Main Authors: Röver, Lea Kristin, Gevensleben, Heidrun, Dietrich, Jörn, Bootz, Friedrich, Landsberg, Jennifer, Goltz, Diane, Dietrich, Dimo
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835568/
https://ncbi.nlm.nih.gov/pubmed/29396294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.01.016
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