PD-1 (PDCD1) Promoter Methylation Is a Prognostic Factor in Patients With Diffuse Lower-Grade Gliomas Harboring Isocitrate Dehydrogenase (IDH) Mutations

Immune checkpoints are important targets for immunotherapies. However, knowledge on the epigenetic modification of immune checkpoint genes is sparse. In the present study, we investigated promoter methylation of CTLA4, PD-L1, PD-L2, and PD-1 in diffuse lower-grade gliomas (LGG) harboring isocitrate...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Röver, Lea Kristin, Gevensleben, Heidrun, Dietrich, Jörn, Bootz, Friedrich, Landsberg, Jennifer, Goltz, Diane, Dietrich, Dimo
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835568/
https://ncbi.nlm.nih.gov/pubmed/29396294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.01.016
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