Detailed analysis of adenosine A2a receptor (ADORA2A) and CD73 (5′-nucleotidase, ecto, NT5E) methylation and gene expression in head and neck squamous cell carcinoma patients

Background: The adenosine A2a receptor (A2aR) and the adenosine synthesizing enzyme CD73 have recently evolved as a novel immunotherapeutic target. However, little is known about epigenetic modification of the encoding genes ADORA2A and NT5E. Methods: In the present study, we evaluated methylation a...

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Publicat a:Oncoimmunology
Autors principals: Vogt, Timo J., Gevensleben, Heidrun, Dietrich, Jörn, Kristiansen, Glen, Bootz, Friedrich, Landsberg, Jennifer, Goltz, Diane, Dietrich, Dimo
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2018
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6136855/
https://ncbi.nlm.nih.gov/pubmed/30221045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1452579
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