Selective α-Synuclein Knockdown in Monoamine Neurons by Intranasal Oligonucleotide Delivery: Potential Therapy for Parkinson’s Disease

Progressive neuronal death in brainstem nuclei and widespread accumulation of α-synuclein are neuropathological hallmarks of Parkinson’s disease (PD). Reduction of α-synuclein levels is therefore a potential therapy for PD. However, because α-synuclein is essential for neuronal development and funct...

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Vydáno v:Mol Ther
Hlavní autoři: Alarcón-Arís, Diana, Recasens, Ariadna, Galofré, Mireia, Carballo-Carbajal, Iria, Zacchi, Nicolás, Ruiz-Bronchal, Esther, Pavia-Collado, Rubén, Chica, Rosario, Ferrés-Coy, Albert, Santos, Marina, Revilla, Raquel, Montefeltro, Andrés, Fariñas, Isabel, Artigas, Francesc, Vila, Miquel, Bortolozzi, Analia
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2018
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835151/
https://ncbi.nlm.nih.gov/pubmed/29273501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.11.015
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