Intracerebral Administration of a Ligand-ASO Conjugate Selectively Reduces α-Synuclein Accumulation in Monoamine Neurons of Double Mutant Human A30P*A53T*α-Synuclein Transgenic Mice

α-Synuclein (α-Syn) protein is involved in the pathogenesis of Parkinson’s disease (PD). Point mutations and multiplications of the α-Syn, which encodes the SNCA gene, are correlated with early-onset PD, therefore the reduction in a-Syn synthesis could be a potential therapy for PD if delivered to t...

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Bibliografske podrobnosti
izdano v:Int J Mol Sci
Main Authors: Pavia-Collado, Rubén, Cóppola-Segovia, Valentín, Miquel-Rio, Lluís, Alarcón-Aris, Diana, Rodríguez-Aller, Raquel, Torres-López, María, Paz, Verónica, Ruiz-Bronchal, Esther, Campa, Leticia, Artigas, Francesc, Montefeltro, Andrés, Revilla, Raquel, Bortolozzi, Analia
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8001805/
https://ncbi.nlm.nih.gov/pubmed/33805843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22062939
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