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Precise Excision of the CAG Tract from the Huntingtin Gene by Cas9 Nickases
Huntington's disease (HD) is a progressive autosomal dominant neurodegenerative disorder caused by the expansion of CAG repeats in the first exon of the huntingtin gene (HTT). The accumulation of polyglutamine-rich huntingtin proteins affects various cellular functions and causes selective dege...
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| Pubblicato in: | Front Neurosci |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5834764/ https://ncbi.nlm.nih.gov/pubmed/29535594 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2018.00075 |
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