Respecifying human iPSC-derived blood cells into highly engraftable hematopoietic stem and progenitor cells with a single factor

Derivation of human hematopoietic stem cells (HSCs) from induced pluripotent stem cells (iPSCs) offers considerable promise for cell therapy, disease modeling, and drug screening. However, efficient derivation of functional iPSC-derived HSCs with in vivo engraftability and multilineage potential rem...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Tan, Yu-Ting, Ye, Lin, Xie, Fei, Beyer, Ashley I., Muench, Marcus O., Wang, Jiaming, Chen, Zhu, Liu, Han, Chen, Sai-Juan, Kan, Yuet Wai
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834708/
https://ncbi.nlm.nih.gov/pubmed/29386396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718446115
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