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Humanized neuronal chimeric mouse brain generated by neonatally engrafted human iPSC-derived primitive neural progenitor cells

The creation of a humanized chimeric mouse nervous system permits the study of human neural development and disease pathogenesis using human cells in vivo. Humanized glial chimeric mice with the brain and spinal cord being colonized by human glial cells have been successfully generated. However, gen...

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Dades bibliogràfiques
Publicat a:JCI Insight
Autors principals: Chen, Chen, Kim, Woo-Yang, Jiang, Peng
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111502/
https://ncbi.nlm.nih.gov/pubmed/27882348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88632
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