Inhibition of dihydrotestosterone synthesis in prostate cancer by combined frontdoor and backdoor pathway blockade

Androgen deprivation therapy (ADT) is palliative and prostate cancer (CaP) recurs as lethal castration-recurrent/resistant CaP (CRPC). One mechanism that provides CaP resistance to ADT is primary backdoor androgen metabolism, which uses up to four 3α-oxidoreductases to convert 5α-androstane-3α,17β-d...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Fiandalo, Michael V., Stocking, John J., Pop, Elena A., Wilton, John H., Mantione, Krystin M., Li, Yun, Attwood, Kristopher M., Azabdaftari, Gissou, Wu, Yue, Watt, David S., Wilson, Elizabeth M., Mohler, James L.
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2018
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834294/
https://ncbi.nlm.nih.gov/pubmed/29541409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24107
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires