Inhibition of dihydrotestosterone synthesis in prostate cancer by combined frontdoor and backdoor pathway blockade

Androgen deprivation therapy (ADT) is palliative and prostate cancer (CaP) recurs as lethal castration-recurrent/resistant CaP (CRPC). One mechanism that provides CaP resistance to ADT is primary backdoor androgen metabolism, which uses up to four 3α-oxidoreductases to convert 5α-androstane-3α,17β-d...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Fiandalo, Michael V., Stocking, John J., Pop, Elena A., Wilton, John H., Mantione, Krystin M., Li, Yun, Attwood, Kristopher M., Azabdaftari, Gissou, Wu, Yue, Watt, David S., Wilson, Elizabeth M., Mohler, James L.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834294/
https://ncbi.nlm.nih.gov/pubmed/29541409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24107
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