Prostate Cancer Cells Differ in Testosterone Accumulation, Dihydrotestosterone Conversion, and Androgen Receptor Signaling Response to Steroid 5α-Reductase Inhibitors

BACKGROUND: Blocking 5α-reductase-mediated testosterone conversion to dihydrotestosterone (DHT) with finasteride or dutasteride is the driving hypothesis behind two prostate cancer prevention trials. Factors affecting intracellular androgen levels and the androgen receptor (AR) signaling axis need t...

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Autori principali: Wu, Yue, Godoy, Alejandro, Azzouni, Faris, Wilton, John H., Ip, Clement, Mohler, James L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3999702/
https://ncbi.nlm.nih.gov/pubmed/23813697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.22694
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