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Adrenal Androgens Rescue Prostatic Dihydrotestosterone Production and Growth of Prostate Cancer Cells after Castration

Adrenal androgens dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) are potential substrates for intracrine production of testosterone (T) and dihydrotestosterone (DHT), or directly to DHT, by prostate cancer (PCa) cells. Production of DHT from DHEAS and DHEA, and the role of steroid sulfatase...

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Detalhes bibliográficos
Publicado no:Mol Cell Endocrinol
Main Authors: Wu, Yue, Tang, Li, Azabdaftari, Gissou, Pop, Elena, Smith, Gary J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6438375/
https://ncbi.nlm.nih.gov/pubmed/30807787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2019.02.018
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