High prevalence of mutant KRAS in circulating exosome-derived DNA from early-stage pancreatic cancer patients

BACKGROUND: Exosomes arise from viable cancer cells and may reflect a different biology than circulating cell-free DNA (cfDNA) shed from dying tissues. We compare exosome-derived DNA (exoDNA) to cfDNA in liquid biopsies of patients with pancreatic ductal adenocarcinoma (PDAC). PATIENTS AND METHODS:...

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Vydáno v:Ann Oncol
Hlavní autoři: Allenson, K., Castillo, J., San Lucas, F. A., Scelo, G., Kim, D. U., Bernard, V., Davis, G., Kumar, T., Katz, M., Overman, M. J., Foretova, L., Fabianova, E., Holcatova, I., Janout, V., Meric-Bernstam, F., Gascoyne, P., Wistuba, I., Varadhachary, G., Brennan, P., Hanash, S., Li, D., Maitra, A., Alvarez, H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Original articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834026/
https://ncbi.nlm.nih.gov/pubmed/28104621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdx004
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