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Epigenetic inhibition of Wnt pathway suppresses osteogenic differentiation of BMSCs during osteoporosis

Disrupted Wnt signaling in osteoblastic-lineage cells leads to bone formation defect in osteoporosis. However, the factors repressing Wnt signaling are unclear. In our study, we found that Wnt signaling was suppressed persistently in bone marrow-derived mesenchymal stem cells (BMSCs) during osteopor...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Jing, Huan, Su, Xiaoxia, Gao, Bo, Shuai, Yi, Chen, Ji, Deng, Zhihong, Liao, Li, Jin, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833865/
https://ncbi.nlm.nih.gov/pubmed/29416009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0231-0
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