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Epigenetic inhibition of Wnt pathway suppresses osteogenic differentiation of BMSCs during osteoporosis

Disrupted Wnt signaling in osteoblastic-lineage cells leads to bone formation defect in osteoporosis. However, the factors repressing Wnt signaling are unclear. In our study, we found that Wnt signaling was suppressed persistently in bone marrow-derived mesenchymal stem cells (BMSCs) during osteopor...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Jing, Huan, Su, Xiaoxia, Gao, Bo, Shuai, Yi, Chen, Ji, Deng, Zhihong, Liao, Li, Jin, Yan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833865/
https://ncbi.nlm.nih.gov/pubmed/29416009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0231-0
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