U-box ubiquitin ligase PPIL2 suppresses breast cancer invasion and metastasis by altering cell morphology and promoting SNAI1 ubiquitination and degradation

Metastasis is the leading cause of breast cancer fatalities. To develop new therapeutic strategies, the mechanisms underlying breast cancer invasion and metastasis need to be further investigated. Peptidylprolyl isomerase (cyclophilin)-like 2 (PPIL2) is a U-box-type E3 ubiquitin ligase belonging to...

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Vydáno v:Cell Death Dis
Hlavní autoři: Jia, Zhaojun, Wang, Miao, Li, Shujing, Li, Xiahui, Bai, Xiao-Yan, Xu, Zhaowei, Yang, Yangyang, Li, Bowen, Li, Yanan, Wu, Huijian
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833831/
https://ncbi.nlm.nih.gov/pubmed/29352246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0094-4
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