U-box ubiquitin ligase PPIL2 suppresses breast cancer invasion and metastasis by altering cell morphology and promoting SNAI1 ubiquitination and degradation

Metastasis is the leading cause of breast cancer fatalities. To develop new therapeutic strategies, the mechanisms underlying breast cancer invasion and metastasis need to be further investigated. Peptidylprolyl isomerase (cyclophilin)-like 2 (PPIL2) is a U-box-type E3 ubiquitin ligase belonging to...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Jia, Zhaojun, Wang, Miao, Li, Shujing, Li, Xiahui, Bai, Xiao-Yan, Xu, Zhaowei, Yang, Yangyang, Li, Bowen, Li, Yanan, Wu, Huijian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833831/
https://ncbi.nlm.nih.gov/pubmed/29352246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0094-4
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