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Arginase-II activates mTORC1 through myosin-1b in vascular cell senescence and apoptosis
Type-II L-arginine:ureahydrolase, arginase-II (Arg-II), is shown to activate mechanistic target of rapamycin complex 1 (mTORC1) pathway and contributes to cell senescence and apoptosis. In an attempt to elucidate the underlying mechanism, we identified myosin-1b (Myo1b) as a mediator. Overexpression...
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| Izdano u: | Cell Death Dis |
|---|---|
| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5833809/ https://ncbi.nlm.nih.gov/pubmed/29472548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0356-9 |
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