Histone deacetylase inhibitors protect against cisplatin-induced acute kidney injury by activating autophagy in proximal tubular cells

Histone deacetylase inhibitors (HDACi) have therapeutic effects in models of various renal diseases including acute kidney injury (AKI); however, the underlying mechanism remains unclear. Here we demonstrate that two widely tested HDACi (suberoylanilide hydroxamic acid (SAHA) and trichostatin A (TSA...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Liu, Jing, Livingston, Man J., Dong, Guie, Tang, Chengyuan, Su, Yunchao, Wu, Guangyu, Yin, Xiao-Ming, Dong, Zheng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833747/
https://ncbi.nlm.nih.gov/pubmed/29476062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0374-7
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