Protein Kinase Cδ Suppresses Autophagy to Induce Kidney Cell Apoptosis in Cisplatin Nephrotoxicity

Nephrotoxicity is a major adverse effect in cisplatin chemotherapy, and renoprotective approaches are unavailable. Recent work unveiled a critical role of protein kinase Cδ (PKCδ) in cisplatin nephrotoxicity and further demonstrated that inhibition of PKCδ not only protects kidneys but enhances the...

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Bibliographic Details
Published in:J Am Soc Nephrol
Main Authors: Zhang, Dongshan, Pan, Jian, Xiang, Xudong, Liu, Yu, Dong, Guie, Livingston, Man J., Chen, Jian-Kang, Yin, Xiao-Ming, Dong, Zheng
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2017
Subjects:
Basic Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373445/
https://ncbi.nlm.nih.gov/pubmed/27799485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016030337
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