Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration

Treatment of intervertebral disc degeneration (IDD) seeks to prevent senescence and death of nucleus pulposus (NP) cells. Previous studies have shown that sirt6 exerts potent anti-senescent and anti-apoptotic effects in models of age-related degenerative disease. However, it is not known whether sir...

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Publicado en:Cell Death Dis
Main Authors: Chen, Jian, Xie, Jun-Jun, Jin, Meng-Yun, Gu, Yun-Tao, Wu, Cong-Cong, Guo, Wei-Jun, Yan, Ying-Zhao, Zhang, Zeng-Jie, Wang, Jian-Le, Zhang, Xiao-Lei, Lin, Yan, Sun, Jia-Li, Zhu, Guang-Hui, Wang, Xiang-Yang, Wu, Yao-Sen
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833741/
https://ncbi.nlm.nih.gov/pubmed/29352194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0085-5
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