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Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration

Treatment of intervertebral disc degeneration (IDD) seeks to prevent senescence and death of nucleus pulposus (NP) cells. Previous studies have shown that sirt6 exerts potent anti-senescent and anti-apoptotic effects in models of age-related degenerative disease. However, it is not known whether sir...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Cell Death Dis
Asıl Yazarlar: Chen, Jian, Xie, Jun-Jun, Jin, Meng-Yun, Gu, Yun-Tao, Wu, Cong-Cong, Guo, Wei-Jun, Yan, Ying-Zhao, Zhang, Zeng-Jie, Wang, Jian-Le, Zhang, Xiao-Lei, Lin, Yan, Sun, Jia-Li, Zhu, Guang-Hui, Wang, Xiang-Yang, Wu, Yao-Sen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833741/
https://ncbi.nlm.nih.gov/pubmed/29352194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0085-5
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