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Phosphorylation of ULK1 by AMPK is essential for mouse embryonic stem cell self-renewal and pluripotency

Autophagy is a catabolic process to degrade both damaged organelles and aggregated proteins in somatic cells. We have recently identified that autophagy is an executor for mitochondrial homeostasis in embryonic stem cell (ESC), and thus contribute to stemness regulation. However, the regulatory and...

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Dettagli Bibliografici
Pubblicato in:Cell Death Dis
Autori principali: Gong, Jiaqi, Gu, Haifeng, Zhao, Lin, Wang, Liang, Liu, Pinglei, Wang, Fuping, Xu, Haoyu, Zhao, Tongbiao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833692/
https://ncbi.nlm.nih.gov/pubmed/29348566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0054-z
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