Optineurin-mediated mitophagy protects renal tubular epithelial cells against accelerated senescence in diabetic nephropathy

Premature senescence is a key process in the progression of diabetic nephropathy (DN). Premature senescence of renal tubular epithelial cells (RTEC) in DN may result from the accumulation of damaged mitochondria. Mitophagy is the principal process that eliminates damaged mitochondria through PTEN-in...

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Bibliografische gegevens
Gepubliceerd in:Cell Death Dis
Hoofdauteurs: Chen, Kehong, Dai, Huanzi, Yuan, Junjie, Chen, Jia, Lin, Lirong, Zhang, Weiwei, Wang, Limin, Zhang, Jianguo, Li, Kailong, He, Yani
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833650/
https://ncbi.nlm.nih.gov/pubmed/29367621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0127-z
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