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Optineurin-mediated mitophagy protects renal tubular epithelial cells against accelerated senescence in diabetic nephropathy

Premature senescence is a key process in the progression of diabetic nephropathy (DN). Premature senescence of renal tubular epithelial cells (RTEC) in DN may result from the accumulation of damaged mitochondria. Mitophagy is the principal process that eliminates damaged mitochondria through PTEN-in...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Chen, Kehong, Dai, Huanzi, Yuan, Junjie, Chen, Jia, Lin, Lirong, Zhang, Weiwei, Wang, Limin, Zhang, Jianguo, Li, Kailong, He, Yani
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833650/
https://ncbi.nlm.nih.gov/pubmed/29367621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0127-z
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