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Optineurin-mediated mitophagy protects renal tubular epithelial cells against accelerated senescence in diabetic nephropathy

Premature senescence is a key process in the progression of diabetic nephropathy (DN). Premature senescence of renal tubular epithelial cells (RTEC) in DN may result from the accumulation of damaged mitochondria. Mitophagy is the principal process that eliminates damaged mitochondria through PTEN-in...

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Bibliografske podrobnosti
izdano v:Cell Death Dis
Main Authors: Chen, Kehong, Dai, Huanzi, Yuan, Junjie, Chen, Jia, Lin, Lirong, Zhang, Weiwei, Wang, Limin, Zhang, Jianguo, Li, Kailong, He, Yani
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833650/
https://ncbi.nlm.nih.gov/pubmed/29367621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0127-z
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