Rosmarinic acid attenuates cardiac fibrosis following long-term pressure overload via AMPKα/Smad3 signaling

Agonists of peroxisome proliferator-activated receptor gamma (PPAR-γ) can activate 5′ AMP-activated protein kinase alpha (AMPKα) and exert cardioprotective effects. A previous study has demonstrated that rosmarinic acid (RA) can activate PPAR-γ, but its effect on cardiac remodeling remains largely u...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Zhang, Xin, Ma, Zhen-Guo, Yuan, Yu-Pei, Xu, Si-Chi, Wei, Wen-Ying, Song, Peng, Kong, Chun-Yan, Deng, Wei, Tang, Qi-Zhu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833382/
https://ncbi.nlm.nih.gov/pubmed/29367637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0123-3
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