Sirtuin 1 activation attenuates cardiac fibrosis in a rodent pressure overload model by modifying Smad2/3 transactivation

AIMS: Transforming growth factor β1 (TGF-β1) is a prosclerotic cytokine involved in cardiac remodelling leading to heart failure (HF). Acetylation/de-acetylation of specific lysine residues in Smad2/3 has been shown to regulate TGF-β signalling by altering its transcriptional activity. Recently, the...

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Detalhes bibliográficos
Publicado no:Cardiovasc Res
Main Authors: Bugyei-Twum, Antoinette, Ford, Christopher, Civitarese, Robert, Seegobin, Jessica, Advani, Suzanne L, Desjardins, Jean-Francois, Kabir, Golam, Zhang, Yanling, Mitchell, Melissa, Switzer, Jennifer, Thai, Kerri, Shen, Vanessa, Abadeh, Armin, Singh, Krishna K, Billia, Filio, Advani, Andrew, Gilbert, Richard E, Connelly, Kim A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148332/
https://ncbi.nlm.nih.gov/pubmed/29800064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvy131
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