High glucose induces Smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy

BACKGROUND: Despite advances in the treatment of heart failure, mortality remains high, particularly in individuals with diabetes. Activated transforming growth factor beta (TGF-β) contributes to the pathogenesis of the fibrotic interstitium observed in diabetic cardiomyopathy. We hypothesized that...

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Detalhes bibliográficos
Main Authors: Bugyei-Twum, Antoinette, Advani, Andrew, Advani, Suzanne L, Zhang, Yuan, Thai, Kerri, Kelly, Darren J, Connelly, Kim A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4108062/
https://ncbi.nlm.nih.gov/pubmed/24886336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2840-13-89
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