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High glucose induces Smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy
BACKGROUND: Despite advances in the treatment of heart failure, mortality remains high, particularly in individuals with diabetes. Activated transforming growth factor beta (TGF-β) contributes to the pathogenesis of the fibrotic interstitium observed in diabetic cardiomyopathy. We hypothesized that...
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主要な著者: | , , , , , , |
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フォーマット: | Artigo |
言語: | Inglês |
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BioMed Central
2014
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オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4108062/ https://ncbi.nlm.nih.gov/pubmed/24886336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2840-13-89 |
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